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Endothelin 1
E7764 -
≥97% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym: ET-1
CAS Number: 117399-94-7
Empirical Formula (Hill Notation): C109H159N25O32S5
Molecular Weight: 2491.90
MDL number: MFCD00133305
PubChem Substance ID: 24894656
Properties
| Related Categories | Agonists, Application Index, Cell Signaling Enzymes, Chymase and Related Products, Endothelins, |
| assay | ≥97% (HPLC) |
| form | powder |
| color | white |
| solubility | 1% acetic acid: >1 mg/mL |
| H2O: >1 mg/mL | |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... EDN1(1906) |
Description
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-M
Other Notes
A synthetic peptide with the sequence of human and porcine Endothelin 1.
The biological source is human endothelin, which shares the same sequence
Biochem/physiol Actions
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Price and Availability
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Documents
Certificate of Analysis
Certificate of Origin
| E7764 - Product Information Sheet (22 KB) |
| Celltransmissions 20(1) (100 KB ) |
| Endothelin Receptors (184 KB ) |
| Endothelin Receptors (82 KB ) |
| Neuropeptidases (252 KB) |
| Neuropeptidases Classification (197 KB ) |
| Gene Information |
| Structure Search |  |
| Similar Products |
Safety Information
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
| RTECS | KE9446500 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
Wong-Dusting, et al., Effect of endothelin-1 on responses of isolated blood vessels to vasoconstrictor agonists.,. J. Cardiovasc. Pharmacol. 17, S236-S238, (1991) Abstract
Ono, et al., Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents. Nature 370, 252-253, (1994) Abstract
Koyama, Y., et al., Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components. Neuroscience 101, 219-227, (2000) Abstract
Russell, F.D., and Molenaar, P., The human heart endothelin system: ET-1 synthesis, storage, release and effect. Trends Pharmacol. Sci. 21, 353-359, (2000) Abstract
Masaki, T., et al., Subcellular mechanisms of endothelin action in vascular system. Eur. J. Pharmacol. 375, 133-138, (1999) Abstract
Inoue, A., et al., The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U. S. A. 86, 2863-2867, (1989) Abstract
Spinella, F., et al., Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1α in ovarian carcinoma cells. J. Biol. Chem. 277, 27850-27855, (2002) Abstract
Brown, M.V., et al., PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp. Cell Res. 315, 39-49, (2009) Abstract
Peng, Y., et al., Agonist-induced nuclear export of GFP-HDAC5 in isolated adult rat ventricular myocytes. J. Pharmacol. Toxicol. Methods 59, 135-40, (2009) Abstract
Zhao, Z.S., et al., Mouse hepatic portal venoconstrictive response to vasoconstrictors is much weaker than that in rat. J. Cardiovasc. Pharmacol. 54, 421-6, (2009) Abstract
Liao, X., et al., Kruppel-like Factor 4 Regulates Pressure-induced Cardiac Hypertrophy. J. Mol. Neurosci. 49, 334-8, (2010)
Merck 14,3576
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